Endocrine Abstracts

Although over 50 type 2 diabetes (T2D) loci have been identified through genome-wide association studies (GWAS), the vast majority of the genetic predisposition to T2D still remains to be clarified. One explanation is that despite the use of high-throughput genotyping arrays, only a small proportion of genetic variants in the human genome are actually surveyed, especially in non-European populations. We explored the comprehensive catalog of genomic variations provided by the 1...

In the perinatal period iodine deficiency results in growth and mental impairment in fetus and newborns. However, there are limited data on iodine metabolism in mother and infants during this critical period.Objective: To assess the changes in urinary iodine concentration (UIC) in mothers and neonates.Methods: From July 2010 to October 2011, 155 pregnant women(31.1±2.1 years) without thyroid disease and their term infants (38....

Japan has been regarded as a nongoitorous country due to the regular intake of iodine-rich food. However, nationwide information on current status of iodine intake is not available because there is no survey system for iodine nutrition in Japan.Objective: The objectives of this study is to characterize current iodine status in Japan.Methods: Since 2002 we have conducted studies on iodine nutrition in the Metropolitan area including...